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Positive findings on bone scan in multiple myeloma.

N J Murthy1, H Rao, A S Friedman

  • 1Department of Medicine, Coney Island Hospital, Brooklyn, NY 11223, USA.

Southern Medical Journal
|January 9, 2001
PubMed
Summary

Bone scans using technetium Tc 99m methylene diphosphonate show high uptake in multiple myeloma bone lesions. Bone scintigraphy is more sensitive than radiography for detecting myeloma-related osteolytic lesions in the ribs, scapula, and spine.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Multiple myeloma frequently causes osteolytic bone lesions.
  • Conventional skeletal radiography is standard for detecting these lesions.
  • The role of bone scintigraphy in multiple myeloma diagnosis is debated.

Purpose of the Study:

  • To evaluate the utility of bone scintigraphy in diagnosing multiple myeloma bone lesions.
  • To compare the sensitivity of bone scans versus radiography for detecting osteolytic lesions.

Main Methods:

  • Case report of multiple myeloma with high technetium Tc 99m methylene diphosphonate uptake in bone lesions.
  • Literature review comparing conventional radiography and bone scans for myeloma-related osteolytic lesions.

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Main Results:

  • Bone scintigraphy demonstrated high uptake in the reported myeloma bone lesions.
  • Literature review indicates bone scintigraphy is more sensitive than radiography for detecting lesions in the ribs, scapula, and spine.
  • Many clinicians underestimate the role of bone scintigraphy in myeloma detection.

Conclusions:

  • Bone scintigraphy is a sensitive tool for detecting multiple myeloma osteolytic bone lesions.
  • Nuclear medicine imaging, specifically bone scans, should be considered in the diagnostic workup of multiple myeloma.
  • Radiologists and oncologists should be aware of the enhanced sensitivity of bone scintigraphy in specific skeletal regions.