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Related Experiment Videos

The cutaneous microcirculation.

I M Braverman1

  • 1Department of Dermatology, Yale Medical School, New Haven, Connecticut 06510, USA. irwin.braverman@yale.edu

The Journal of Investigative Dermatology. Symposium Proceedings
|January 9, 2001
PubMed
Summary
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The skin

Area of Science:

  • Dermatology and microcirculation research.
  • Investigating the structural and functional organization of skin vasculature.

Background:

  • The skin's microcirculation comprises two horizontal plexuses connected by ascending arterioles and descending venules.
  • Nutritive capillary loops originate from the upper plexus, with smooth muscle sphincters regulating flow.
  • Valved collecting veins at the dermal-subcutaneous junction prevent retrograde blood flow.

Purpose of the Study:

  • To elucidate the microvascular architecture of the skin.
  • To explore the application of Laser Doppler flowmetry (LDF) in characterizing skin microcirculation.
  • To correlate microvascular structure with functional measurements for studying physiological and pathological states.

Main Methods:

  • Utilizing electron and light microscopy to define microvascular segments.

Related Experiment Videos

  • Employing Laser Doppler flowmetry (LDF) to measure red cell flux and concentration of moving red blood cells.
  • Correlating LDF data with skin biopsies to create topographic maps of microvascular composition.

    • Main Results:

    • LDF identified vasomotion in ascending arterioles, indicating functional regulation.
    • Simultaneous LDF measurements enabled topographic mapping of arteriolar and venular composition within 1 mm³ skin volumes.
    • Combined microscopic and LDF data allowed differentiation of skin regions based on microvascular predominance.

    Conclusions:

    • The study provides a detailed map of skin microcirculation, integrating structural and functional data.
    • Laser Doppler flowmetry is a valuable tool for in vivo characterization of skin microvascular dynamics.
    • This approach facilitates the study of both normal skin physiology and disease pathogenesis involving microvascular dysfunction.