Related Experiment Video
Updated: Oct 9, 2026
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Perinatal risk factors related to neurologic outcomes of term newborns with asphyxia at birth: a prospective study
H Asakura1, H Ichikawa, M Nakabayashi
1Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Objectives:
The incidence of poor neurologic outcomes was studied in term newborns who had suffered severe asphyxia at birth.
Methods:
Subjects were 152 newborns admitted to the NICU with a low Apgar score at 1 or 5 minutes. A 1-year prospective follow-up of neurological outcomes was carried out by a questionnaire survey concluded between April 1, 1996 and March 31, 1998.
Results:
1) The incidence of a poor neurologic outcome, including 15 neurologic sequelae and 6 deaths, was 13.8% among the subjects. 2) The risk of a poor outcome was increased by 13-fold in neonates with adverse neurological signs and 31-fold in those with hypoxic ischemic encephalopathy.
Conclusion:
The incidence of poor neurologic outcome was very high among term infants with low Apgar scores. These infants were 10 times to 20 times more likely to die, or to survive with permanent disabilities, than were infants without low Apgar scores.
