Related Experiment Video
Updated: Oct 9, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
Published on: February 15, 2022
Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation
H Koyama1, K E Bornfeldt, S Fukumoto
1Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. hidekoyama@med.osaka-cu.ac.jp
Abstract:
Cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) are second messengers involved in the intracellular signal transduction of a wide variety of extracellular stimuli. These signals regulate many biological processes including cell proliferation, differentiation, migration, and apoptosis. Recently, significant progress has been achieved in the molecular basis underlying cyclic nucleotide regulation of cell proliferation. This review summarizes our knowledge of the signaling pathways regulated by cyclic nucleotides in arterial smooth muscle cells.
Related Concept Videos
Nitric Oxide Signaling Pathway
Antihypertensive Drugs: Action of Calcium Channel Blockers
Inhibition of Cdk Activity
Inhibition of CDK Activity
Smooth Muscle Contraction
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
Amplifying Signals via Second Messengers

