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Related Experiment Videos

Neurophysiologic tests during antidepressive treatment - an exploratory study.

H D Sattler1, P Richter, M Fritzsche

  • 1Department of Psychiatry, University of Heidelberg, Germany.

Pharmacopsychiatry
|January 9, 2001
PubMed
Summary

Tricyclic antidepressants (TCA) significantly alter autonomic nervous system function, indicated by impaired sympathetic skin response (SSR) and heart rate variation (HRV). Serotonin-reuptake inhibitors (SSRI) showed no significant autonomic side-effects in this study.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Autonomic Nervous System

Background:

  • Antidepressant medications can cause autonomic side-effects.
  • Neurophysiological parameters offer a sensitive measure of autonomic function.

Purpose of the Study:

  • To investigate the sensitivity of neurophysiological parameters in detecting autonomic side-effects of antidepressants.
  • To compare the effects of tricyclic antidepressants (TCA) and serotonin-reuptake inhibitors (SSRI) on autonomic nervous system function.

Main Methods:

  • A non-randomized exploratory study involving 48 participants: TCA group, SSRI group, and healthy controls.
  • Neurophysiological examinations included sympathetic skin response (SSR) latency and amplitude, and heart rate variation (HRV).
  • Nerve conduction velocity (NCV) and F-wave were used to exclude peripheral nerve affections.

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Main Results:

  • The TCA group exhibited delayed SSR latencies and smaller SSR amplitudes compared to controls.
  • No significant differences in SSR parameters were observed between the SSRI group and controls.
  • HRV analysis further supported impaired autonomic nervous system adjustment in the TCA group.

Conclusions:

  • Tricyclic antidepressants (TCA) induce specific alterations in autonomic nervous system function.
  • Neurophysiological testing, particularly SSR and HRV, can detect TCA-related autonomic side-effects.
  • SSRI medications did not demonstrate significant autonomic side-effects in this study population.