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Updated: Oct 9, 2026

Minimal Erythema Dose (MED) Testing
Published on: May 28, 2013
[Efficiency of etidronic acid in the case of cutaneous radiocontamination by actinid elements: in vitro evaluation]
H Tymen1, D Hoffschir, P Gerasimo
1Laboratoire de contrôle radiotoxicologique, Service de Protection Radiologique des Armées, 1 bis, rue du Lieutenant Raoul Batany, F 92141, Clamart Cedex.
Abstract:
Ethane 1 hydroxy 1.1. biphosphonate (EHBP) is a medicine named Didronel, which inhibits bone resorption in the case of Paget's disease. This molecule could offer a new application in radiotoxicology. Our works describe its efficiency as decontaminating agent in uranium and plutonium cutaneous radiocontamination. Its effect on uranium and plutonium is demonstrated by two in vitro techniques using human cutaneous explants. Both techniques are usually used in dermopharmacology to estimate the action of topic drugs.
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