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Sildenafil inhibits gastroduodenal motility
M Bortolotti1, C Mari, C Lopilato
1Department of Internal Medicine and Gastroenterology, University of Bologna, Italy. bortolottim@orsola-malpighi.med.unibo.it
Alimentary Pharmacology & Therapeutics
|January 10, 2001
Summary
Sildenafil significantly reduces antrum and duodenum motility by inhibiting phosphodiesterase-5. This study shows sildenafil impacts gastroduodenal muscle activity, affecting digestive processes.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Sildenafil inhibits phosphodiesterase-5, impacting smooth muscle cells in corpus cavernosum arterioles.
- The mechanism involves blocking cyclic guanosine monophosphate inactivation.
Purpose of the Study:
- To determine if sildenafil's inhibitory effect extends to the gastroduodenal tract musculature.
- Investigating sildenafil's impact on digestive motility.
Main Methods:
- A double-blind, placebo-controlled study involving 16 healthy subjects.
- Antroduodenal motility was measured using manometry after administering sildenafil (50 mg) or placebo.
- Analysis focused on wave frequency, amplitude, and phase durations over 90 minutes.
Main Results:
- Sildenafil significantly decreased antral and duodenal wave frequency and amplitude.
- The duration of phases I in both antrum and duodenum was prolonged by sildenafil.
- Sildenafil reduced the occurrence of phase III of the migrating motor complex.
Conclusions:
- Sildenafil demonstrates an inhibitory effect on the interdigestive motor activity of the stomach's antrum and the duodenum.
- These findings suggest sildenafil influences upper gastrointestinal motility.