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Multiple primary melanomas.

J J Stam-Posthuma1, C van Duinen, E Scheffer

  • 1Department of Dermatology and Pathology, Leiden University Medical Center, The Netherlands.

Journal of the American Academy of Dermatology
|January 10, 2001
PubMed
Summary
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Individuals with dysplastic nevi or a family history of melanoma face increased risk for multiple melanomas. Early onset and specific nevus diagnoses are key indicators for melanoma development.

Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Patients with clinically diagnosed dysplastic nevi or a family history of melanoma are at higher risk for developing multiple melanomas.
  • This risk is present with or without histologically diagnosed dysplastic nevi.

Purpose of the Study:

  • To identify factors that increase the risk of developing subsequent melanomas.
  • To analyze the characteristics of patients who develop multiple melanomas.

Main Methods:

  • Retrospective study involving 56 patients.
  • Analysis of data from 157 melanomas.

Main Results:

  • High prevalence of early age at onset (58.9%), clinically diagnosed dysplastic nevi (82.0%), and family history of melanoma (64.7%).

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  • Mean age at diagnosis was 38.2 years, with a mean interval of 34.3 months between first and second melanomas.
  • Second melanomas often appeared in different regions (76.8%), and mean tumor thickness decreased (1.11 mm to 0.90 mm).

    • Conclusions:

    • Genetic factors may play a role in a subset of patients with early and successive melanoma development.
    • Identifying risk factors like dysplastic nevi and family history is crucial for early detection and management.