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Changes in frequency and severity of limited joint mobility in children with type 1 diabetes mellitus between 1976-78

J R Infante1, A L Rosenbloom, J H Silverstein

  • 1Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA.

The Journal of Pediatrics
|January 10, 2001
PubMed

Insights

Limited joint mobility (LJM) in type 1 diabetes has significantly decreased over 20 years. This improvement in LJM prevalence suggests better diabetes management and reduced long-term complication risks.

Area of Science:

  • Endocrinology
  • Diabetology
  • Pediatric Endocrinology

Background:

  • Limited joint mobility (LJM) is an early complication of type 1 diabetes mellitus (T1DM).
  • LJM is a risk indicator for microvascular complications.
  • Metabolic control significantly influences LJM development.

Purpose of the Study:

  • To investigate the change in LJM prevalence in children and adolescents with T1DM over two decades.
  • To test the hypothesis that LJM prevalence has decreased.

Main Methods:

  • A cohort of 312 T1DM subjects (aged 7-18) was examined using consistent methodology.
  • Data from 515 subjects from 1976-1978 were used for comparison.
  • Statistical analyses included chi-squared tests, t-tests, and logistic regression.

Main Results:

  • A >4-fold reduction in LJM frequency was observed between 1976-78 (31%) and 1998 (7%).
  • The proportion of patients with moderate or severe LJM also decreased significantly (35% vs 9%).

Conclusions:

  • The study confirms a significant decrease in LJM prevalence in T1DM patients over 20 years.
  • Improved glycemic control is the likely reason for this reduction in LJM.
Abstract

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