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Early neonatal brain injury in histologic chorioamnionitis
De Felice C1, P Toti, R N Laurini
1Department of Preventive Pediatrics and Neonatology, the Institute of Pathology, University of Siena, Siena, Italy.
The Journal of Pediatrics
|January 10, 2001
Abstract:
The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of periventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage > or =3 (3.5; 2.4-5.2), and seizures (2.3; 1.4-3.7).