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Growth hormone deficiency caused by pituitary stalk interruption in Fanconi's anemia
S Dupuis-Girod1, E Gluckman, J C Souberbielle
1Pediatric Endocrinology and Immuno-Hematology Departments, Physiology Laboratory, Université René Descartes and Hôpital Necker-Enfants Malades, Paris, France.
The Journal of Pediatrics
|January 10, 2001
Abstract:
Fanconi's anemia can be associated with growth retardation. We describe biologic growth hormone deficiency, isolated or associated with thyrotropin abnormality, and pituitary stalk interruption syndrome on magnetic resonance imaging of 5 patients with Fanconi's anemia. Growth hormone treatment produced catch-up growth in all cases. These findings suggest a common genetic origin.