Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central neurocytomas express photoreceptor differentiation.

H Mena1, A L Morrison, R V Jones

  • 1Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

Cancer
|January 10, 2001
PubMed
Summary

Central neurocytomas are slow-growing tumors typically found in the brain ventricles. These tumors show neuronal and glial markers, with some expressing photoreceptor differentiation, and are associated with long patient survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multilayer Electrolyzer Stack Converts Carbon Dioxide to Gas Products at High Pressure with High Efficiency.

ACS energy letters·2019
Same author

Lead and zinc dust depositions from ore trains characterised using lead isotopic compositions.

Environmental science. Processes & impacts·2015
Same author

Fulminant and fatal encephalitis caused by Acanthamoeba in a kidney transplant recipient: case report and literature review.

Transplant infectious disease : an official journal of the Transplantation Society·2013
Same author

Cancer survival in Costa Rica, 1995-2000.

IARC scientific publications·2011
Same author

Local Chemotherapy as a Curative Measure.

British medical journal·2010
Same author

Photoneural systems: an introduction.

Applied optics·2010

Area of Science:

  • Neuro-oncology
  • Neuropathology
  • Cellular Differentiation

Background:

  • Central neurocytomas (CNs) are neuronal tumors often exhibiting rosette formation, similar to pineocytomas.
  • This morphological similarity suggests potential shared differentiation pathways, including photoreceptor differentiation.

Purpose of the Study:

  • To analyze the clinicopathologic features and immunoreactivity of central neurocytomas.
  • To investigate the potential for photoreceptor differentiation and correlation between histologic features and clinical behavior.

Main Methods:

  • Clinicopathologic analysis of 33 central neurocytoma cases.
  • Immunohistochemical evaluation using markers for neuronal, glial, neuroendocrine, and retinal S-antigen.

Main Results:

Related Experiment Videos

  • Tumors were primarily located in the ventricles, with mineralization being a common feature.
  • Immunohistochemistry revealed strong expression of neuronal markers (synaptophysin, neuron-specific enolase) and variable expression of S-100 protein and retinal S-antigen.
  • No significant anaplastic features were observed, and patients generally had favorable outcomes with long survival post-surgery.

Conclusions:

  • Central neurocytomas are indolent neoplasms with a favorable prognosis, typically confined to the supratentorial ventricles.
  • The expression of retinal S-antigen suggests photoreceptor differentiation, linking CNs to pineocytomas.
  • Adipocyte differentiation may also occur, suggesting a potential relationship with liponeurocytomas.