Related Experiment Videos
Pharmacologic and potential biologic interventions to restore bladder function after spinal cord injury
N Yoshimura1, C P Smith, M B Chancellor
1Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA. nyos+@pitt.edu
Current Opinion in Neurology
|January 10, 2001
Summary
Spinal cord injury impairs bladder control by disrupting neural pathways. This review examines therapeutic strategies aimed at restoring lower urinary tract function after such injuries.
Area of Science:
- Neuroscience
- Urology
- Rehabilitation Medicine
Background:
- Spinal cord injury (SCI) significantly impacts neurological function, leading to loss of voluntary control over urination.
- The complex interplay between the bladder and urethral sphincter is disrupted, causing voiding dysfunction after SCI.
Purpose of the Study:
- To review and synthesize findings from animal and human studies on therapeutic approaches for lower urinary tract function after SCI.
- To identify effective strategies for normalizing bladder and urethral sphincter coordination post-SCI.
Main Methods:
- Comprehensive literature search of studies evaluating therapeutic interventions for SCI-induced urinary dysfunction.
- Analysis of research focusing on both preclinical animal models and clinical human trials.
Main Results:
- Various therapeutic strategies have been investigated to restore bladder function after SCI.
- Evidence from animal and human studies suggests potential pathways for improving urinary control.
Conclusions:
- Restoring lower urinary tract function after spinal cord injury remains a significant clinical challenge.
- Continued research into therapeutic interventions is crucial for improving the quality of life for individuals with SCI.