Related Experiment Video
Updated: Jul 11, 2026

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
Published on: October 27, 2010
Pesticides and parkinsonism: is there an etiological link?
Abstract:
Two hundred years ago, Parkinson's disease was rare. Now, it is the second most common neurodegenerative disorder. A recent twin study showed clearly that genetic factors play a minor role in determining whether an individual develops this disease, rekindling an interest in the etiological significance of environmental factors. Earlier studies had shown that a MPTP, a contaminant found in some illegal drugs, caused Parkinson's disease. This provided the original impetus for the pesticide hypothesis. Similarities between MPTP and pesticides coupled with epidemiological and animal studies have strengthened the possible link between pesticide exposure and the subsequent development of Parkinson's disease.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

