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Synthesis and antimicrobial activity of new 2-phenylethynylbenzothiazoles and related salts
P Magdolen1, P Zahradník, P Foltínová
1Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
Arzneimittel-Forschung
|January 10, 2001
Abstract:
New 2-phenylethynylbenzothiazoles were synthesized by coupling reaction between 2-iodobenzothiazole and substituted phenylacetylenes under palladium catalysis. The modified Wittig reaction was used to prepare the substituted phenylacetylenes from corresponding benzaldehydes. 2-Phenylethynylbenzothiazoles were next quarternized with trimethyloxonium tetrafluoroborate to 3-methylbenzothiazolium salts. Antimicrobial in vitro activities were determined for all new compounds.