Simultaneous measurement of effective hepatic blood flow and systemic circulation

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Updated: Oct 9, 2026

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
10:40

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model

Published on: August 4, 2012

M Hashimoto1, G Watanabe

  • 1Department of Digestive Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan.

Hepato-Gastroenterology
|January 10, 2001
PubMed

Insights

Indocyanine green clearance measures liver function and systemic circulation. In cirrhosis, hyperdynamic circulation may compensate for impaired hepatic function, highlighting the need for simultaneous assessment.

Area of Science:

  • Hepatology
  • Cardiovascular Physiology
  • Clinical Diagnostics

Background:

  • Indocyanine green (ICG) disappearance rate reflects both hepatocyte function and hepatic blood flow.
  • Systemic circulation significantly influences ICG clearance, a crucial factor in liver function assessment.
  • Cirrhotic patients often exhibit a hyperdynamic state despite slower ICG clearance.

Purpose of the Study:

  • To simultaneously evaluate hepatic function and systemic circulation in cirrhotic patients.
  • To investigate the role of the hyperdynamic state in compensating for impaired liver function.
  • To establish the utility of simultaneous ICG clearance measurements for liver function studies.

Main Methods:

  • Simultaneous measurement of effective hepatic blood flow and systemic circulation using an indocyanine green clearance meter.
  • Quantitative calculation of effective hepatic blood flow based on ICG early disappearance rate, cardiac output, and circulating time.
  • Random selection of 46 patients for comprehensive hemodynamic and liver function assessment.

Main Results:

  • Quantitative evaluation of hepatic function and hyperdynamic circulation was achieved.
  • In normal subjects, ICG disappearance rate correlated with cardiac index.
  • Cirrhotic patients displayed reduced ICG clearance despite a relatively high cardiac index, indicating impaired hepatic function masked by hyperdynamic circulation.

Conclusions:

  • The indocyanine green clearance meter enables simultaneous assessment of hepatic function and systemic circulation.
  • Hyperdynamic circulation appears to be a compensatory mechanism for impaired hepatic function in cirrhotic livers.
  • Simultaneous measurement of hepatic and systemic circulation is essential for accurate liver function evaluation.
Abstract

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