Related Experiment Video

Updated: Sep 21, 2026

Surgical Management of Meatal Stenosis with Meatoplasty
04:53

Surgical Management of Meatal Stenosis with Meatoplasty

Published on: November 30, 2010

Acute poststreptococcal glomerulonephritis following circumcision

V Tasic1, M Polenakovic

  • 1Department of Pediatric Nephrology, Clinic for Children's Diseases, University Clinical Center, 017 Vodnjanska, 91000 Skopje, Republic of Macedonia. vtasic@freemail.org.mk

Pediatric Nephrology (Berlin, Germany)
|January 10, 2001
PubMed

Insights

A rare case of acute poststreptococcal glomerulonephritis occurred in an 11-year-old boy after a circumcision wound infection. Prompt diagnosis and treatment led to full recovery, highlighting a potential complication of wound infections.

Area of Science:

  • Nephrology
  • Pediatrics
  • Infectious Diseases

Background:

  • Poststreptococcal glomerulonephritis (PSGN) is an immune complex-mediated kidney disease typically following group A Streptococcus infection.
  • While common in children, PSGN following localized wound infections is less frequently reported.
  • Circumcision is a common procedure, and wound infections can occur, necessitating awareness of potential systemic complications.

Observation:

  • An 11-year-old boy developed oliguria, edema, hematuria, and hypertensive encephalopathy two weeks post-ritual circumcision.
  • The patient's circumcision wound showed signs of infection.
  • Clinical presentation was consistent with acute nephritic syndrome.

Findings:

  • Isolation of Streptococcus pyogenes from the wound confirmed the causative agent.
  • Elevated antistreptolysin O (ASTO) and anti-DNAse B titers indicated a recent streptococcal infection.
  • Hypocomplementemia supported the diagnosis of PSGN.
  • The patient experienced an uneventful recovery with resolution of nephritic signs and normalization of laboratory parameters.

Implications:

  • This case highlights that Streptococcus pyogenes wound infections, including those following circumcision, can trigger acute poststreptococcal glomerulonephritis.
  • It underscores the importance of vigilant wound care and prompt diagnosis of infections after procedures.
  • This represents the first reported instance of PSGN following a circumcision wound infection, expanding the spectrum of known PSGN etiologies.

More Related Videos

Microscopic Replantation of Penile Glans Amputation Due to Circumcision07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis03:55

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...