Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypercalcemia caused by generalized sarcoidosis].

T Hierl1, M Libicher, P Nawroth

  • 1Abteilung Innere Medizin I, Ruprecht-Karls-Universität Heidelberg.

Deutsche Medizinische Wochenschrift (1946)
|January 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carnosinase Gene-Is It Responsible for Diabetic Nephropathy?: Carnosine as a Protective Factor in Diabetic Nephropathy: Association with a Leucine Repeat of the Carnosinase Gene CNDP1. Diabetes 54: 2320-2327, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Pronounced cortisol response to acute psychosocial stress in type 2 diabetes patients with and without complications.

Hormones and behavior·2022
Same author

Intracardial PMMA bone cement embolism after kyphoplasty-an unusual cause for sudden chest pain, hemothorax and hemopericardium.

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

[Hypercalcemic crisis and hypocalcemic tetany].

Der Internist·2017
Same author

[Prevention of aortic erosion by a bone cement skid : Thoracic endovascular aortic repair following kyphoplasty].

Der Orthopade·2016
Same author

Low-dose erythropoietin promotes wound-healing of ulcers in diabetics: Evidence from a phase-IIa clinical study.

Diabetes & metabolism·2016

This study reports a case of hypercalcemia in a patient with sarcoidosis, where elevated calcium levels were not due to high vitamin D. Macrophage-derived cytokines likely contributed to bone resorption and hypercalcemia.

Area of Science:

  • Nephrology
  • Endocrinology
  • Immunology

Background:

  • Sarcoidosis is a multisystem inflammatory disease that can affect calcium homeostasis.
  • Hypercalcemia in sarcoidosis is often associated with elevated 1,25-dihydroxyvitamin D3 levels due to extrarenal production.

Observation:

  • A 70-year-old man with a history of kidney stones presented with hypercalcemia and sensory neuropathy.
  • Investigations revealed generalized sarcoidosis affecting the mediastinum, vertebrae, and peripheral nerves.
  • Despite normal vitamin D metabolite levels and reduced parathormone, the patient had prolonged hypercalcemia.

Findings:

  • Magnetic resonance imaging (MRI) identified lymphomacrophagocytic infiltration in the vertebrae, suggesting a localized cause for bone resorption.
  • Glucocorticoid treatment normalized serum calcium levels within two weeks.

Related Experiment Videos

  • The findings suggest that cytokine secretion by macrophages may play a significant role in sarcoidosis-associated hypercalcemia, independent of elevated vitamin D.

    • Implications:

    • This case highlights that hypercalcemia in sarcoidosis can occur without elevated 1,25-dihydroxyvitamin D3.
    • Cytokine-mediated bone resorption should be considered in the pathogenesis of hypercalcemia in sarcoidosis, particularly when vitamin D levels are normal.
    • Understanding these mechanisms can guide therapeutic strategies for managing hypercalcemia in sarcoidosis.