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Updated: Oct 9, 2026

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
Published on: October 17, 2017
Mean pressures and flows in the human intracranial system as determined by mathematical simulations of a steady-state
1Department of Mathematics and Statistics, University of Vermont, VT, USA. stevens@selway.umt.edu
Abstract:
In order to understand the fluid dynamics within the human intracranial system, the relatively small flow of extracellular fluid into, and out of, the interstitial brain tissue must be determined. Due to the magnitude of these flows, it is difficult to measure them clinically. Through a steady-state infusion simulation run on a mathematical model, values for these small flows may be calculated based on clinical data regarding the conductance of cerebrospinal fluid outflow. In this way, the mathematical model allows information to be obtained regarding these small mean flows, as well as the remaining mean flows and mean pressures throughout the intracranial space, with minimal reliance on data from intrusive procedures.
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