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Related Experiment Videos

True hermaphroditism: 10 years' experience.

Z D Krstić1, Z Smoljanić, D Vukanić

  • 1University Children's Hospital, Belgrade, Yugoslavia.

Pediatric Surgery International
|January 10, 2001
PubMed
Summary

True hermaphroditism (TH), a rare intersex condition, involves both ovarian and testicular tissue. Early diagnosis and raising patients as females are crucial for optimal outcomes.

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Area of Science:

  • Endocrinology
  • Genetics
  • Pediatric Surgery

Background:

  • True hermaphroditism (TH) is an exceptionally rare intersex malformation characterized by the presence of both ovarian and testicular tissue.
  • Patients often present with ambiguous genitalia or gynecomastia, necessitating careful evaluation and management.
  • This study reviews a cohort of TH patients treated over a decade to analyze clinical presentations and outcomes.

Purpose of the Study:

  • To analyze the clinical characteristics, management, and outcomes of patients diagnosed with true hermaphroditism.
  • To evaluate the long-term results of gender assignment in patients with TH.
  • To emphasize the importance of early diagnosis and appropriate gender assignment in managing TH.

Main Methods:

  • Retrospective review of 4 patients with true hermaphroditism treated between 1986 and 1996.
  • Analysis of patient karyotypes, gonadal tissue, external genitalia, and assigned gender.
  • Documentation of surgical interventions, pubertal development, and functional outcomes.

Main Results:

  • Four patients with TH were identified, all with separate testicular and ovarian tissues.
  • Karyotypes included 46,XY (3 patients) and 46,XX (1 patient); gender assignments were male (3) and female (1).
  • Surgical interventions ranged from 3 to 9 procedures per patient; long-term outcomes included hypogenitalism in males and successful intercourse after vaginoplasty in the female patient.

Conclusions:

  • Most patients with true hermaphroditism should be raised as females to achieve better functional and social outcomes.
  • Early diagnosis and intervention are critical for optimizing management and long-term results in TH.
  • This case series supports the current recommendation for female gender assignment in the majority of TH patients.

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