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1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz

W A Smith1, J M Arif, R C Gupta

  • 1Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington 40536-0305, USA.

International Journal of Cancer
|January 10, 2001
PubMed

Insights

1,2-dithiole-3-thione (D3T) and oltipraz show promise as cancer chemopreventive agents. D3T effectively inhibited DNA adduction by dibenzo-[a,l]pyrene across all tissues studied.

Area of Science:

  • Chemoprevention
  • Cancer Research
  • Molecular Toxicology

Background:

  • Dithiolethiones are a promising class of cancer chemopreventive agents.
  • They exhibit antitumorigenic properties against various carcinogens.
  • Their efficacy against specific carcinogen-DNA adducts requires further investigation.

Purpose of the Study:

  • To evaluate the chemopreventive effects of 1,2-dithiole-3-thione (D3T) and oltipraz.
  • To assess their impact on DNA adduction induced by dibenzo-[a,l]pyrene (DBP) in vivo.
  • To compare the efficacy of D3T and oltipraz in different tissues.

Main Methods:

  • Female Sprague-Dawley rats were fed diets containing D3T or oltipraz (500 ppm).
  • Animals received a single dose of dibenzo-[a,l]pyrene (DBP).
  • DBP-DNA adduction levels were measured in various tissues 5 days post-exposure.

Main Results:

  • D3T significantly inhibited DBP-DNA adduction by 78-82% in all examined tissues.
  • Oltipraz showed similar efficacy in the lung and liver but was less effective (approx. 60% inhibition) in mammary glands.
  • These findings highlight differential tissue-specific effects of the two dithiolethiones.

Conclusions:

  • D3T demonstrates broad-spectrum inhibition of DBP-induced DNA adduction.
  • Oltipraz also exhibits chemopreventive effects, with notable efficacy in mammary glands.
  • Both D3T and oltipraz show potential for cancer prevention and warrant further clinical investigation.

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