Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinoic acid and CO2 laser resurfacing.

W S McDonald1, D Beasley, C Jones

  • 1University of Miami School of Medicine, Fla., USA. wsmcd@worldnet.att.net

Plastic and Reconstructive Surgery
|January 10, 2001
PubMed
Summary

Retinoic acid pretreatment may reduce CO2 laser resurfacing injury depth and accelerate wound healing in guinea pigs. This finding suggests potential benefits for skin regeneration and recovery after laser procedures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.

Cancer research·1996
Same author

Early and periodic screening diagnosis and treatment.

Archives of pediatrics & adolescent medicine·1996
Same author

Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting.

Gene·1996
Same author

Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: pathological and immunocytochemical changes.

Acta neuropathologica·1996
Same author

Insulin resistance in patients with essential hypertension can occur in the absence of microalbuminuria.

American journal of hypertension·1996
Same author

Mouse monoclonal antipeptide antibodies specific for cholesteryl ester transfer protein (CETP).

Hybridoma·1996

Area of Science:

  • Dermatology
  • Laser Surgery
  • Wound Healing Research

Background:

  • Carbon dioxide (CO2) laser resurfacing is a common dermatological procedure.
  • Understanding factors that influence healing and injury depth is crucial for optimizing outcomes.
  • Retinoic acid is known for its effects on skin cell proliferation and differentiation.

Purpose of the Study:

  • To investigate the impact of retinoic acid pretreatment on wound healing and injury depth following CO2 laser resurfacing.
  • To evaluate histological changes in guinea pig skin after laser treatment with and without retinoic acid.

Main Methods:

  • 21 Hartley guinea pigs were used, with dorsal skin halves treated daily with 0.05% retinoic acid or as control.
  • Animals were divided into three groups receiving one, two, or three passes of CO2 laser resurfacing.

Related Experiment Videos

  • Histological analysis was performed pre-laser and at days 1, 4, and 7 post-resurfacing to measure injury depth, thickness, cell layers, and epithelialization rates.

    • Main Results:

    • Pretreatment with retinoic acid resulted in a statistically significant reduction in the depth of laser-induced injury.
    • Granular cell layers were thicker and more numerous at day 4 in retinoic acid pretreated animals compared to controls.
    • Wound healing appeared to be accelerated in animals pretreated with retinoic acid.

    Conclusions:

    • Pretreatment with retinoic acid may mitigate the depth of injury associated with CO2 laser resurfacing.
    • Retinoic acid application shows potential to enhance the rate of wound healing after laser skin procedures.