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Related Experiment Video

Updated: Jul 6, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

IL-12/IL-13 axis in allergic asthma.

¹Division of Immunobiology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, OH 45299-3039, USA.

The Journal of Allergy and Clinical Immunology

|January 10, 2001

Summary

An imbalance in interleukin-12 (IL-12) and interleukin-13 (IL-13) cytokine production is linked to allergic airway diseases like asthma. This imbalance, with overproduced IL-13 and underproduced IL-12, may drive allergic responses.

Area of Science:

Immunology
Allergology
Genetics

Background:

Allergic airway diseases involve skewed T helper 2 (T(H)2) cytokine production.
Interleukin-12 (IL-12) and Interleukin-13 (IL-13) are key cytokines in T(H)2 responses to allergens.

Purpose of the Study:

To investigate the role of the IL-12/IL-13 axis in allergic airway diseases.
To explore the imbalance in IL-12 and IL-13 production in atopic and asthmatic individuals.

Main Methods:

Review of existing evidence on IL-12 and IL-13 in allergic responses.
Analysis of genetic associations with asthma and atopy related to IL-12 and IL-13 genes.

Main Results:

IL-13 overproduction and IL-12 deficiency are observed in allergic individuals.

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IL-13 overproduction contributes to allergic symptoms like airway hyperresponsiveness and IgE production.

Genetic studies suggest a link between IL-13 gene alterations and atopy/asthma.

Conclusions:

An imbalance in the IL-12/IL-13 axis is implicated in the development of allergic diseases, including asthma.
Further research into the relationship between IL-12 and IL-13 is warranted.