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Convenient substitute indices to toxic equivalent quantity for controlling and monitoring dioxins in stack gas from

M Kato1, K Urano

  • 1Yokohama National University, Laboratory of Safety and Environmental Engineering, 79-5, Tokiwadai, Hodogaya-ku, Yokohama, Japan.

Waste Management (New York, N.Y.)
|January 10, 2001
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...