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Pyrrolidine PNA: a novel conformationally restricted PNA analogue
A Püschl1, T Tedeschi, P E Nielsen
1Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Biochemistry Laboratory B, The Panum Institute, Blegdamsvej 3C, DK-2200, Copenhagen, Denmark. ask@kiku.dk
Organic Letters
|January 11, 2001
Abstract:
[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.