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Synthesis and initial structure--activity relationships of modified salicylihalamides
Y Wu1, O R Seguil, J K De Brabander
1Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038, USA.
Organic Letters
|January 11, 2001
Abstract:
[reaction:see text] The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.