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T-helper type 2 cell-directed therapy for asthma.

L Cohn1, A Ray

  • 1Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, 06520-8057, New Haven, CT, USA. lauren.cohn@yale.edu

Pharmacology & Therapeutics
|January 11, 2001
PubMed
Summary

T-helper type 2 (Th2) cells and their cytokines drive asthma pathogenesis. This review explores Th2 cell mechanisms and discusses current and novel immunotherapies targeting Th2 responses for asthma treatment.

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Area of Science:

  • Immunology
  • Respiratory Medicine
  • Allergy

Background:

  • Asthma is a chronic airway inflammation.
  • T-helper type 2 (Th2) cells and cytokines are implicated in asthma pathology.
  • Understanding Th2 cell roles is crucial for effective asthma management.

Purpose of the Study:

  • To review evidence linking Th2 cells to asthma.
  • To discuss mechanisms controlling Th2 cell differentiation in the airways.
  • To explore therapeutic strategies targeting Th2 responses.

Main Methods:

  • Literature review of human and animal studies.
  • Analysis of cellular and molecular mechanisms of Th2 differentiation.
  • Discussion of traditional and novel immunomodulatory therapies.

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Main Results:

  • Th2 cells and their cytokines are key drivers of asthma.
  • Th2 cell differentiation is regulated by specific cellular and molecular pathways.
  • Existing therapies can modulate Th2 function, while new strategies aim to block differentiation or neutralize cytokines.

Conclusions:

  • Th2 cells are central to asthma pathophysiology.
  • Targeting Th2 cell differentiation and function offers promising therapeutic avenues.
  • Future treatments may involve blocking Th2 responses or redirecting immunity toward Th1 pathways.