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Related Experiment Videos

Tissue factor-dependent factor VIIa signaling.

L C Petersen1, P Freskgård, M Ezban

  • 1Novo Nordisk A/S, Health Care Discovery, Tissue Factor/Factor VII Research, Novo Nordisk Park, Måløv, Denmark.

Trends in Cardiovascular Medicine
|January 11, 2001
PubMed
Summary
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Tissue factor (TF) initiates blood coagulation extracellularly. Recent studies reveal TF also triggers intracellular signaling pathways, independent of its cytoplasmic domain, affecting cell functions.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Hematology

Background:

  • Tissue factor (TF) is primarily known as a cofactor in the extrinsic pathway of blood coagulation.
  • Emerging evidence suggests TF engages in intracellular signaling independent of its coagulation role.

Purpose of the Study:

  • To review recent findings on TF-dependent factor VIIa signaling.
  • To highlight the intracellular activities induced by TF-bound factor VIIa.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies investigating TF-mediated intracellular signaling pathways.

Main Results:

  • Factor VIIa bound to cell surface TF can induce intracellular signaling.

Related Experiment Videos

  • This signaling involves Ca(2+) mobilization and p44/p42 MAPK phosphorylation.
  • TF-dependent signaling is independent of the TF cytoplasmic domain and distinct from known protease-activated receptors (PARs).

    • Conclusions:

    • TF possesses signaling functions beyond its role in coagulation.
    • TF-mediated intracellular signaling impacts cellular functions through novel pathways.