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[Morphological alterations of the trabecular meshwork in primary open angle glaucoma]
1Departamento de Anatomía Humana, Facultad de Medicina, Universidad de Barcelona, Barcelona, España. jpotau@med.ub.es
Archivos De La Sociedad Espanola De Oftalmologia
|January 11, 2001
Summary
Primary open angle glaucoma involves structural changes in the trabecular meshwork, affecting aqueous humor drainage. These alterations in glaucomatous eyes offer insights into the disease
Area of Science:
- Ophthalmology
- Cell Biology
- Pathology
Context:
- Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Understanding the structural basis of POAG is crucial for developing effective treatments.
Purpose:
- To compare the morphology and structure of normal and glaucomatous trabecular meshworks.
- To investigate the etiopathogeny of primary open angle glaucoma.
Summary:
- Glaucomatous trabecular meshworks exhibit significant morphological and structural alterations compared to normal ones.
- Observed changes include enlarged and collapsed trabecular beams, endothelial cell loss, and accumulation of pigment and calcium precipitates.
Impact:
- These findings suggest that trabecular meshwork alterations are key factors in the development of primary open angle glaucoma.
- Modified drainage conditions due to these structural changes likely contribute to increased intraocular pressure.