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[Study of topical ketorolac effect on arachidonic acid metabolism in experimental anterior uveitis]
Cuevas Andrés R1, Ruiz Moreno O, Ferrer Novella E
1Servicio de Oftalmología, Hospital Miguel Servet, Zaragoza, España.
Purpose:
To study the effect of topical ketorolac-tromethamine in the arachidonic acid metabolism on a model of endotoxin induced uveitis (EIU) in albino rabbits.
Methods:
EIU was produced by intravitreal injection in the right eye with 10 ng LPS A Salmonella typhimurium endotoxin in 5ul saline solution. We used 60 animals (5 groups of 12 animals each). Control group (G-I) was injected with saline (5 ul); endotoxin group (G-II) was injected with 10 ng of ET; group III, IV and V were injected with the same amount of ET and treated with topical ketorolac-tromethamine every 6, 4 and 2 hours respectively. The animals were sacrificed 24 hours after the ET administration and we determined E2 prostaglandin and B4 leukotriene concentration in the aqueous humor.
Results:
In all treated groups with ketorolac-tromethamine we observed a significant reduction (p<0.05) in aqueous humor concentration of E2 prostaglandin without increase of the B4 leukotriene concentration comparing with endotoxin group.
Conclusions:
Ketorolac tromethamine produced an inhibition of ciclooxigenase metabolism of arachidonic acid without increase of lypoxygenase pathway.
