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[Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study]
Teus Guezala MA1, Arranz Márquez E, Morales Bertrand J
1Servicio de Oftalmología, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
Purpose:
To study the ocular hypotensive effect of pilocarpine in latanoprost treated eyes.
Methods:
We measured the IOP in both eyes of 25 patients, before and after instillation of pilocarpine 2% in one eye, and placebo in the other. This is a prospective, double blind, placebo-controlled study.
Results:
We found that the mean change in IOP of the study eyes was +0.4 on average (range of change from -3 to +5 mmHg), compared with the control, placebo treated eyes (p=0.5).
Conclusions:
The acute administration of pilocarpine in Latanoprost treated eyes seems to have a paradoxical effect on IOP, as the IOP may increase or decrease.