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[Quantitative vascular analysis in the marginal periodontium using PECAM-1]
J Jackowski1, F Straube, S Philippou
1Abteilung für Zahnärztliche Chirurgie, Fakultät für Zahn-, Mund- und Kieferheilkunde, Universität Witten/Herdecke, Alfred-Herrhausen-Strasse 50, 58448 Witten.
Mund-, Kiefer- Und Gesichtschirurgie : MKG
|January 11, 2001
Summary
Systemic sclerosis (SSc) patients show no difference in gingival blood vessel counts compared to periodontitis patients. These findings suggest microvascular changes in SSc are not mirrored in the marginal periodontium.
Area of Science:
- Oral pathology
- Immunohistochemistry
- Connective tissue disorders
Background:
- Systemic sclerosis (SSc) is a fibrotic disease affecting immune, vascular, and connective tissues.
- SSc is characterized by exuberant fibrosis and microvascular abnormalities.
- The oral manifestations of SSc require further investigation.
Purpose of the Study:
- To compare gingival microvasculature in SSc patients versus periodontitis patients.
- To investigate the presence of avascular areas in the subepithelial connective tissue of the marginal periodontium.
- To assess potential links between SSc-related vascular changes and periodontal tissues.
Main Methods:
- Biopsies of marginal gingiva and papilla from 13 SSc and 8 periodontitis patients.
- Immunohistochemical analysis using CD 31 antibody to identify blood vessel profiles.
- Quantification of blood vessel profiles per area and statistical comparison using Mann-Whitney U-test.
Main Results:
- No statistically significant difference in median blood vessel profiles between SSc and periodontitis groups (P=0.665).
- No avascular areas were observed in the subepithelial connective tissue of either group.
- Gingival microvasculature appears comparable between SSc and periodontitis patients.
Conclusions:
- Microvascular pathological changes seen in SSc dermis are not evident in the marginal periodontium.
- Further intraindividual studies comparing dermal and oral mucosal microvasculature in SSc are needed.
- Current findings do not support a direct transfer of SSc microvascular pathology to the marginal periodontium.