[Diagnostic image (16). Sweet's syndrome]

Area of Science:

• Dermatology
• Pathology

Background:

• Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is an inflammatory condition.
• It is characterized by the sudden onset of fever, neutrophilia, and tender, erythematous skin lesions.

Observation:

• A 68-year-old male presented with painful, erythematous, infiltrated nodules and plaques on the face, neck, and hands.
• Clinical presentation suggested Sweet's syndrome.

Findings:

• Histopathological examination revealed massive dermal infiltration by neutrophils.
• Crucially, no evidence of vasculitis was observed, differentiating it from other similar conditions.
• The findings were consistent with the diagnostic criteria for Sweet's syndrome.

Implications:

• This case underscores the importance of histopathological examination in diagnosing Sweet's syndrome.
• Successful treatment with oral corticosteroids confirms their efficacy in managing this condition.
• Early diagnosis and treatment can lead to rapid symptom resolution and prevent complications.