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Unusual pattern of leukoencephalopathy after morphine sulphate intoxication
R Nanan1, H B von Stockhausen, B Petersen
1Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. KINK106@mail.uni-wuerzburg.de
Neuroradiology
|January 11, 2001
Abstract:
We report a 14-year-old girl with an unusual pattern of leukoencephalopathy after intentional intoxication with morphine sulphate tablets. Toxicological analysis showed exceedingly high levels of morphine and its metabolites. MRI disclosed a leukoencephalopathy with high signal from the centrum semiovale, corpus callosum and cerebellar white matter on T2-weighted images. These findings could be only partially explained by a hypoxic-ischaemic event; neurotoxic effects must be considered in this atypical leukoencephalopathy.