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Updated: Aug 6, 2026
10:32
Murine Cervical Heart Transplantation Model Using a Modified Cuff Technique
Published on: October 12, 2014
Endothelin and cardiac transplantation
1Montreal General Hospital, Suite L3.314, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada. Mdga@musica.mcgill.ca
Zeitschrift Fur Kardiologie
|January 11, 2001
Summary
Endothelins, peptides produced by endothelial cells, are implicated in heart failure and transplant coronary artery disease. This review explores endothelin
Area of Science:
- Cardiovascular Biology
- Endocrinology
- Transplantation Medicine
Background:
- Endothelins are vasoactive peptides produced by endothelial cells and other tissues.
- They regulate numerous physiological and pathophysiological processes, including vasoconstriction and cell growth.
- Elevated endothelin levels are linked to heart failure and transplant coronary artery disease.
Purpose of the Study:
- To review the regulation of endothelin in cardiac transplantation.
- To discuss the pathological role of endothelin in post-transplant complications.
Main Methods:
- Literature review of studies on endothelin in cardiac transplantation.
- Analysis of endothelin's role in renal impairment, hypertension, graft rejection, and arteriosclerosis.
Main Results:
- Endothelin plays a significant role in the pathophysiology of cardiac allograft vasculopathy.
- Increased endothelin activity contributes to systemic hypertension and graft rejection.
- Endothelin contributes to arteriosclerosis following heart transplantation.
Conclusions:
- Endothelin is a critical mediator in cardiac transplantation complications.
- Targeting endothelin pathways may offer therapeutic strategies for improving outcomes after heart transplantation.
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