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Cystectomy for severe hemorrhagic cystitis in allogeneic stem cell transplant recipients

L Garderet1, H Bittencourt, P Sebe

  • 1Department of Bone Marrow Transplantation, Saint Louis Hospital, Paris, France.

Transplantation
|January 11, 2001
PubMed

Insights

Severe hemorrhagic cystitis (HC) after stem cell transplantation (SCT) can be life-threatening. In rare cases, cystectomy may be required as a life-saving procedure for prolonged HC.

Area of Science:

  • Hematology
  • Transplantation Medicine
  • Urology

Background:

  • Hemorrhagic cystitis (HC) is a frequent complication post-allogeneic stem cell transplantation (SCT).
  • Severe HC can lead to kidney failure, sepsis, and be life-threatening.

Observation:

  • Three cases of severe HC in stem cell transplant recipients are presented.
  • Patients received high-dose cyclophosphamide with total body irradiation or busulfan.
  • BK viruria was detected in two patients at hematuria onset.

Findings:

  • Severe HC persisted for over 3 months in these patients.
  • Complications included urinary tract obstruction and sepsis.
  • Cystectomy was ultimately performed as a life-saving intervention.

Implications:

  • This case series highlights cystectomy as a critical, last-resort treatment for life-threatening, refractory hemorrhagic cystitis post-SCT.
  • Understanding risk factors and management is crucial for severe HC cases.
Abstract

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