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Related Experiment Videos

Paracetamol (acetaminophen) hypersensitivity.

B J de Paramo1, S Q Gancedo, M Cuevas

  • 1Allergy Department, Ramon y Cajal Hospital, Madrid, Spain.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|January 11, 2001
PubMed
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Adverse reactions to acetaminophen (paracetamol) in four patients were investigated. Results suggest an IgE-mediated mechanism, as patients tolerated aspirin but reacted to acetaminophen.

Area of Science:

  • Immunology
  • Pharmacology
  • Allergy

Background:

  • Acetaminophen (paracetamol) is a common analgesic antipyretic lacking anti-inflammatory effects.
  • Previous reports suggested IgE-mediated reactions to acetaminophen, but evidence was inconclusive.

Purpose of the Study:

  • To demonstrate an IgE-mediated mechanism in four patients experiencing adverse reactions to acetaminophen.
  • To assess acetaminophen hypersensitivity in patients who tolerate aspirin and other NSAIDs.

Main Methods:

  • Four patients with anaphylaxis to acetaminophen and tolerance to NSAIDs were studied.
  • Methods included skin testing, oral challenges with acetaminophen and aspirin, and serum IgE testing.

Main Results:

Related Experiment Videos

  • All patients tolerated aspirin challenges.
  • Acetaminophen challenges elicited adverse reactions in all four patients.
  • Positive skin tests and detectable IgE antibodies to acetaminophen were observed in two patients.

    • Conclusions:

    • Four cases of adverse reactions to acetaminophen with preserved tolerance to aspirin and NSAIDs are presented.
    • Findings suggest an IgE-mediated hypersensitivity mechanism in these acetaminophen reactions.