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Updated: Aug 17, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Biologic responses to IFN-alpha administration in humans
E P Corssmit1, J de Metz, H P Sauerwein
1Department of Endocrinology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands. e.p.corssmit@amc.uva.nl
Abstract:
Although interferon-alpha (IFN-alpha) was discovered over 40 years ago, it was many years before it was registered as a therapeutic agent. Because of its unique qualities, it has been registered for both antiviral and antitumor indications. In addition to its therapeutic effects in viral diseases and cancer, IFN-alpha interferes with several important physiologic systems. It interacts with the immune system and affects several neuroendocrine and metabolic circuits. The specific mechanisms by which IFN-alpha exerts its therapeutic effects are complex, and it is very difficult to tie the biologic actions of IFN-alpha to specific clinical effects.
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