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Effectiveness of high doses of simvastatin as monotherapy in mixed hyperlipidemia
M Miller1, C Dolinar, W Cromwell
1Division of Cardiology, University of Maryland Medical Center, Baltimore, USA. mmiller@heart.umaryland.edu
The American Journal of Cardiology
|January 12, 2001
Abstract:
Twenty subjects with mixed hyperlipidemia participated in a 3-arm crossover trial to evaluate the effectiveness of high-dose simvastatin as monotherapy. Significant reductions were observed in atherogenic lipids and lipoproteins. The highest dose of simvastatin also resulted in significant increases in high-density lipoprotein cholesterol (21%) with a comparable increase in large, protective high-density lipoprotein particles.