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Multiple oscillators, dynamic synchronization and sympathetic control.

M P Gilbey1

  • 1Department of Physiology, University College London, United Kingdom. mpg@rfc.ucl.ac.uk

Clinical and Experimental Pharmacology & Physiology
|January 12, 2001
PubMed
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Sympathetic nerve activity exhibits rhythmic bursts, influenced by internal oscillators and external inputs. Dynamic synchronization of these oscillators is crucial for cardiovascular control and neuroeffector transmission.

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Autonomic Nervous System Research

Background:

  • Sympathetic nerve activity is characterized by intermittent bursts, driven by phasic inputs and intrinsic oscillators.
  • The functional significance of patterned and synchronized neural activity is critical for information transfer and synaptic/neuroeffector function.
  • Understanding sympathetic nervous system control of cardiovascular function relies on studying neuroeffector transmission.

Purpose of the Study:

  • To review laboratory work investigating the functional importance of pattern and synchrony coding in sympathetic nervous control of cardiovascular function.
  • To explore the role of sympathetic neuron discharge patterns and synchronization in regulating blood pressure and heart rate.

Main Methods:

  • Recording sympathetic innervation activity in an anesthetized rat tail artery model.

Related Experiment Videos

  • Analyzing single neuron and population-level sympathetic discharges under steady-state conditions.
  • Investigating the influence of central respiratory drive and afferent inputs on sympathetic oscillator synchronization.

    • Main Results:

    • Sympathetic neuron discharges in the rat tail artery exhibit a distinct rhythm (approx. 0.8 Hz) at both single neuron and population levels.
    • A network of oscillators controls sympathetic discharge, with dynamic synchronization influenced by respiratory drive and visceral/somatic afferent inputs.
    • Weakly coupled or uncoupled oscillators can be dynamically synchronized by various external inputs.

    Conclusions:

    • Pattern and synchrony coding in sympathetic nervous system activity are functionally significant for cardiovascular control.
    • Dynamic synchronization of sympathetic oscillators by external inputs plays a key role in sympathetic pattern generation and neuroeffector transmission.
    • The findings highlight the importance of understanding neural network dynamics in autonomic nervous system regulation.