Electroretinography of acute hypoxic and increased intraocular pressure status in the dog

A model for studying electroretinographic (ERG) responses during controlled hypoxia and acutely increased intraocular pressure (IOP) in dogs is described. The b-wave component of the ERG was critically affected before the a-wave. The critical perfusion pressure (PP) was 45 mm of Hg less than mean arterial blood pressure, and the dog will demonstrate altered b-wave amplitudes at hypoxic values of arterial oxygen pressure (Pao2) 0f 45 torr.