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The control and facilitation of MHC class II antigen processing by the BCR
1Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue, MCV0930, Chicago, IL 60637, USA. ksiemask@midway.uchicago.edu
Current Opinion in Immunology
|January 13, 2001
Abstract:
Antigens capable of cross-linking the BCR are preferentially captured, processed and presented to MHC-class-II-restricted T cells. Cross-linking antigens initiate tyrosine-kinase-dependent pathways that accelerate the delivery of antigen-receptor complexes to specialized late-endocytic processing compartments. Accelerated trafficking is mediated by the recruitment of signaling molecules required for transience through specific checkpoints along the endocytic pathway.