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Updated: Oct 9, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic
I J Marton1, A Rot, E Schwarzinger
1Department of Restorative Dentistry, Institute of Stomatology, Medical School of the University of Debrecen, P.O. Box 13, H-4012 Debrecen, Hungary.
Abstract:
In situ distribution of three prototype chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and Rantes was determined in chronic human periapical granulomas by immunohistochemistry using monoclonal antibodies. IL-8 was found primarily in the cytoplasm of the Malassez epithelial cells. MCP-1 immunoreactivity was confined to the endothelial cells that lined small venules. Each of the three investigated chemokines, including Rantes, exhibited a characteristic binding pattern to the extracellular matrix of the lesion. The observed chemokines may play a role in establishing the cellular composition of chronic apical periodontitis, thus augmenting the intensity of local inflammation and tissue damage.