Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cadmium accumulation in rat liver.

A V Colucci, D Winge, J Krasno

    Archives of Environmental Health
    |March 1, 1975
    PubMed
    Summary

    Cadmium (Cd) accumulation in rat livers and resulting pathology were studied. Hepatic Cd concentration, not injected dose, better predicted pathological changes, indicating liver metal burden is key.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Epidemiological considerations relative to sulfur oxides and particulates.

    Bulletin of the New York Academy of Medicine·2009
    Same author

    Characterization of a human chorionic gonadotropin-like protein from Candida albicans.

    Endocrinology·1993
    Same author

    Stimulation of Candida albicans transition by human chorionic gonadotrophin and a bacterial protein.

    Endocrine research·1992
    Same author

    Uptake of cadmium-109, a metallothionein-binding radiometal, by tumors in mice as a function of the transformed phenotype.

    Investigative radiology·1988
    Same author

    A persistent untranslated sequence within bacteriophage T4 DNA topoisomerase gene 60.

    Science (New York, N.Y.)·1988
    Same author

    X-ray absorption studies of the copper-beta domain of rat liver metallothionein.

    Journal of inorganic biochemistry·1986

    Area of Science:

    • Toxicology
    • Biochemistry
    • Pathology

    Background:

    • Intraperitoneal administration of cadmium (Cd) can induce biochemical and pathological changes.
    • Understanding the dose-response relationship and tissue distribution is crucial for assessing Cd toxicity.

    Purpose of the Study:

    • To investigate the biochemical accumulation and clinical pathological conditions induced by intraperitoneal cadmium administration in Sprague-Dawley rats.
    • To determine the correlation between cadmium dosage, hepatic cadmium concentration, and observed pathological changes.

    Main Methods:

    • Sprague-Dawley rats were administered intraperitoneal injections of cadmium at doses ranging from 0.5 to 3 mg/kg body weight.
    • Distribution studies of cadmium in the liver were conducted.
    • Pathological changes were assessed and correlated with hepatic cadmium concentration and injected dose.

    Main Results:

    • Cadmium in the liver was found to be bound to a soluble protein.
    • Hepatic cadmium concentration increased with increasing injected cadmium dosage.
    • Pathological changes showed a stronger correlation with the concentration of cadmium in the liver than with the injected dose.

    Conclusions:

    • Hepatic accumulation of cadmium is a critical factor in the development of cadmium-induced pathology.
    • The correlation between liver metal concentration and pathology suggests a threshold effect or direct toxic mechanism within the liver.
    • These findings highlight the importance of assessing tissue-specific metal burden in toxicological studies.

    Related Experiment Videos