Cadmium accumulation in rat liver

The biochemical accumulation and clinical pathological conditions induced by intraperitoneal administration of cadmium was studied in Sprague-Dawley rats. Injected doses of cadmium ranging from 0.5 to 3 mg/kg of body weight were administered. Distribution studies of Cd in the liver indicated the metal was bound to a soluble protein, and that the amount of metal present increases with increasing dosage. The pathological changes were found to correlate better with hepatic concentration of metal than with the injected dose.