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Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease

A M Nadroo1, S Shringari, M Garg

  • 1Department of Pediatrics, Maternity and Children Hospital, Riyadh Medical Complex, Riyadh, Kingdom of Saudi Arabia. Anadroo@yahoo.com

Journal of Perinatal Medicine
|January 13, 2001
PubMed

Insights

Prolonged prostaglandin therapy in neonates can cause hyperostosis and musculoskeletal changes. Other side effects include abnormal facial features and elevated alkaline phosphatase, suggesting dose and duration dependency.

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Pharmacology

Background:

  • Prostaglandin therapy is crucial for neonates with cyanotic heart disease.
  • Prolonged use may lead to adverse effects, particularly musculoskeletal changes.

Purpose of the Study:

  • To investigate the side effects of extended prostaglandin therapy in neonates.
  • Specifically focusing on hyperostosis and other musculoskeletal alterations.

Main Methods:

  • Retrospective review of case files of neonates with cyanotic heart disease receiving prostaglandin infusion.
  • Analysis of radiographs, serum alkaline phosphatase levels, and prostaglandin dosage/duration.

Main Results:

  • Ten patients developed hyperostosis after 9-195 days of PGE1 infusion.
  • Two neonates exhibited coarse facial features, hypertrichosis, edema, and digital swelling.
  • Significantly elevated serum alkaline phosphatase was observed in patients with hyperostosis, including clavicular involvement.

Conclusions:

  • Hyperostosis is a frequent adverse effect of prolonged prostaglandin therapy.
  • Long-term therapy can also cause abnormal facial features and skin changes.
  • Serum alkaline phosphatase serves as a marker for hyperostosis, which can affect clavicles and is dose/duration dependent.
Abstract

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