Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dapsone and sulfapyridine.

U Paniker1, N Levine

  • 1Section of Dermatology, University of Arizona College of Medicine, Tucson, Arizona, USA.

Dermatologic Clinics
|January 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infant oral health care.

Canadian family physician Medecin de famille canadien·2011
Same author

Dental care for the handicapped.

Canadian family physician Medecin de famille canadien·2011
Same author

What hospitalization means to the mental patient, the community, and the hospital social worker.

Mental hygiene·2010
Same author

The mental patient in the community from the viewpoint of the family agency.

Mental hygiene·2010
Same author

White lesions on the lip.

Geriatrics·2002
Same author

Tender papule on the ear.

Geriatrics·2001

Dapsone and sulfapyridine are key drugs for leprosy, HIV-related Pneumocystis pneumonia, and dermatitis herpetiformis. Monitoring for toxic side effects like hemolysis is crucial due to their hydroxylamine metabolite.

Area of Science:

  • Pharmacology
  • Dermatology
  • Infectious Diseases

Background:

  • Dapsone and sulfapyridine are structurally similar drugs with antimicrobial and anti-inflammatory properties.
  • Dapsone is a primary treatment for leprosy and prophylaxis for Pneumocystis pneumonia in HIV patients.
  • Sulfapyridine serves as an alternative for dapsone-intolerant dermatitis herpetiformis patients.

Purpose of the Study:

  • To review the therapeutic applications of dapsone and sulfapyridine.
  • To highlight their efficacy in various dermatological and infectious conditions.
  • To discuss the toxicological profile and monitoring recommendations for these drugs.

Main Methods:

  • Literature review of dapsone and sulfapyridine applications.
  • Analysis of drug mechanisms and side effects.

Related Experiment Videos

  • Summary of clinical guidelines for treatment and monitoring.

    • Main Results:

    • Dapsone is essential for leprosy and Pneumocystis pneumonia prophylaxis.
    • Dermatitis herpetiformis and other neutrophilic disorders respond to these agents.
    • Adverse effects including hemolysis, methemoglobinemia, and agranulocytosis are linked to the hydroxylamine metabolite.

    Conclusions:

    • Dapsone and sulfapyridine are valuable therapeutics for specific conditions.
    • Understanding their toxicological profile is vital for safe patient management.
    • Regular blood counts and chemistry profiles are necessary to monitor for adverse reactions.