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Autoimmune thyroiditis in children with Turner syndrome.
1Department of Pediatrics, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.
Journal of the Formosan Medical Association = Taiwan Yi Zhi
|January 13, 2001
Summary
Autoimmune thyroiditis (AIT) is common in children with Turner syndrome, with a 36% cumulative frequency at 10 years. Regular thyroid monitoring is crucial for early detection and treatment of potential thyroid dysfunction.
Area of Science:
- Pediatric Endocrinology
- Autoimmunology
- Genetics
Background:
- Turner syndrome is a chromosomal disorder affecting females.
- Thyroid dysfunction is a known complication in Turner syndrome.
- Autoimmune thyroiditis (AIT) involves the immune system attacking the thyroid gland.
Purpose of the Study:
- To determine the frequency of autoimmune thyroiditis (AIT) in children with Turner syndrome.
- To assess the risk of developing thyroid dysfunction in these patients.
- To evaluate the necessity of regular thyroid monitoring.
Main Methods:
- Prospective follow-up of 77 children with Turner syndrome over 10 years.
- Regular assessment of antithyroglobulin antibody, antimicrosomal antibody, and thyroid function every 6 months.
- Analysis of data including age at diagnosis and antibody detection.
Main Results:
- AIT was detected in 27% of patients, with a cumulative frequency of 36% at 10 years.
- 14% of patients with AIT developed thyroid dysfunction (hypothyroidism or hyperthyroidism).
- Both patients with a ring X chromosome developed AIT.
Conclusions:
- Taiwanese children with Turner syndrome have a high frequency of AIT.
- A significant proportion of these patients develop thyroid dysfunction.
- Regular thyroid autoantibody and function monitoring is essential for timely diagnosis and treatment.