The neuroscience of depression in adolescence

The neuroscience of depression in children and adolescents has only recently become a focus of research. Initially, techniques previously used for adult investigations were employed, such as endocrine studies and sleep studies. Endocrine studies have indicated that, as in adult depression, a dysregulation of the serotonin (5-HT) axis is involved in childhood depression. However, both of these techniques are difficult to perform in children and have yielded some inconsistent results. The more recently developed neuroimaging techniques should enable the greatest advances in our understanding of the pathophysiology of depression. These techniques have already implicated the frontal lobes in the pathogenesis of depression in children and adolescents, and further research is ongoing.