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Somatostatin effects on lower esophageal sphincter function.

D E Bybee, F C Brown, L P Georges

The American Journal of Physiology

|July 1, 1979

Summary

Somatostatin (GH-RIH) infusion did not alter basal lower esophageal sphincter pressure (LESP) or responses to direct stimulation. However, GH-RIH abolished LESP increases induced by intragastric alkali and glycine.

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Area of Science:

Gastroenterology
Endocrinology
Physiology

Background:

The lower esophageal sphincter (LES) regulates gastroesophageal reflux.
Hormonal regulation of LES pressure (LESP) is not fully understood.
Somatostatin (GH-RIH) is a hormone with diverse physiological effects.

Purpose of the Study:

To investigate the effect of somatostatin (GH-RIH) infusion on lower esophageal sphincter pressure (LESP) responses to various stimuli in adult male baboons.
To determine if GH-RIH modulates basal LESP or LESP responses to hormonal, neural, or mechanical stimuli.

Main Methods:

Adult male baboons received continuous infusion of somatostatin (GH-RIH).
LESP was measured at baseline and in response to pentagastrin, abdominal compression, intragastric alkali, and intragastric glycine.

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Cholinergic response was assessed using atropine.

Main Results:

GH-RIH infusion did not affect basal LESP.
GH-RIH did not alter LESP responses to pentagastrin or abdominal compression (cholinergic response).
GH-RIH completely abolished LESP increases induced by intragastric alkali and glycine, suggesting inhibition of a hormonal mechanism.

Conclusions:

Somatostatin (GH-RIH) does not influence basal LESP or LES responses to direct smooth muscle stimulation or cholinergic input.
GH-RIH inhibits LESP responses to intragastric alkali and glycine, indicating a role in suppressing hormonally mediated mechanisms affecting the LES.