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Nephrogenic adenofibroma in a young child
E Guzman1, C Turc-Carel, C Soler
1Laboratoire d'Anatomie Pathologique, H spital Pasteur, CHU Nice, France. anapath@chu-nice.fr
Pathology, Research and Practice
|January 13, 2001
Summary
Nephrogenic adenofibroma, a rare benign renal tumor, was diagnosed in an infant with hematuria. This case highlights diagnostic challenges and the importance of distinguishing it from other pediatric renal tumors.
Area of Science:
- Pediatric Oncology
- Nephropathology
Background:
- Nephrogenic adenofibroma is a rare, benign renal tumor affecting children and young adults.
- Distinguishing it from malignant pediatric renal tumors like nephroblastoma and mesoblastic nephroma can be challenging.
Observation:
- The study presents the first reported case of nephrogenic adenofibroma in an 11-month-old infant presenting with macroscopic hematuria.
- The initial diagnosis was difficult, requiring multiple reviews and expert consultation.
Findings:
- Morphologic and immunohistochemical analyses, alongside expert review, led to the diagnosis of nephrogenic adenofibroma with stromal predominance.
- Fluorescence in situ hybridization (FISH) revealed trisomy 11 in tumor cells, a finding common in mesoblastic nephroma but not nephroblastoma.
Implications:
- This case underscores the diagnostic complexities of nephrogenic adenofibroma in pediatric patients.
- The presence of trisomy 11 aids in excluding nephroblastoma but does not definitively differentiate between nephrogenic adenofibroma and mesoblastic nephroma.
- Nephrogenic adenofibroma has an excellent prognosis with no specific treatment indicated.
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